Welcome
to the
smith lab
Understanding molecular mechanisms of motor neuron development & disease
A dual model system approach to study motor neurons
C. elegans
Accessible to -omics
Behavioral (i.e. locomotion) assays
CRISPR/Cas9 genome engineering
Gene discovery tool
Simple invertebrate
Human ESC-derived MNs
Accessible to -omics
CRISPR/Cas9 genome engineering
Functional (e.g. viability) assays
Human context
MN differentiation
Check out our recent work
Structure-Function study of Tol-1/Lat-1 interactions
Nature Structural & Molecular Biology
June 2025
A molecular atlas of adult motor neurons
Cell Reports
March 2024
CFI-1/ARID3 functions in terminal differentiation
Cell Reports
March 2023
Review of Hox genes in C. elegans nervous system
Seminars in Cell & Developmental Biology
Dec. 2022
